Vaccine based on a ubiquitous cysteinyl protease and streptococcal pyrogenic exotoxin A protects against Streptococcus pyogenes sepsis and toxic shock

Table 1 Vaccination and Immune Protection: HLA-DQ8/human CD4 Transgenic Mice

¹Vaccinations at 0, 2 and 4 weeks (3 doses) with 10 μg of SpeA (L42R) or SpeA (L42R)-SpeB (C47S) in adjuvant or adjuvant only.
²Percent mice surviving wild-type SpeA challenge, 5 LD₅₀ per mouse 2 weeks after last vaccination. 5 mice per group SpeA (L42R) and adjuvant only control; 4 mice for SpeA (L42R)-SpeB (C47S) vaccination. Experiments were performed twice with identical results.